Biophysically detailed mathematical models of multiscale cardiac active mechanics.

We propose four novel mathematical models, describing the microscopic mechanisms of force generation in the cardiac muscle tissue, which are suitable for multiscale numerical simulations of cardiac electromechanics. Such models are based on a biophysically accurate representation of the regulatory a...

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Bibliographic Details
Main Authors: Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008294