Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

BackgroundTumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. The objective of the present study was to test the effect of topical versus intracerebroventricular administration of XPro1595 (a solTNF...

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Bibliographic Details
Main Authors: Minna Yli-Karjanmaa, Bettina Hjelm Clausen, Matilda Degn, Hans Gram Novrup, Ditte Gry Ellman, Peter Toft-Jensen, David E. Szymkowski, Allan Stensballe, Morten Meyer, Roberta Brambilla, Kate Lykke Lambertsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Neuroscience
Subjects:
ischemic stroke
behavior
cytokines
microglial activation
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00781/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00781/full

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