The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.

The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and i...

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Bibliographic Details
Main Authors: Saioa López, Oscar García, Iñaki Yurrebaso, Carlos Flores, Marialbert Acosta-Herrera, Hua Chen, Jesús Gardeazabal, Jesús María Careaga, María Dolores Boyano, Ana Sánchez, Juan Antonio Ratón-Nieto, Arrate Sevilla, Isabel Smith-Zubiaga, Alicia García de Galdeano, Conrado Martinez-Cadenas, Neskuts Izagirre, Concepción de la Rúa, Santos Alonso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4122405?pdf=render

Internet

http://europepmc.org/articles/PMC4122405?pdf=render

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