A Rare Complex BRAF Mutation Involving Codon V600 and K601 in Primary Cutaneous Melanoma: Case Report

A Rare Complex BRAF Mutation Involving Codon V600 and K601 in Primary Cutaneous Melanoma: Case Report

BRAF is one of the most common mutated kinases detected in human cancer, particularly in cases of primary cutaneous melanomas (PCM). Mutations of the BRAF proto-oncogene, at the p.V600 codon, has been detected in more than 50% of primary and metastatic melanoma cells in clinical samples. In addition...

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Bibliographic Details
Main Authors: Francesca Consoli, Gianluca Barbieri, Matteo Picciolini, Daniela Medicina, Mattia Bugatti, Valeria Tovazzi, Barbara Liserre, Claudia Zambelli, Fausto Zorzi, Alfredo Berruti, Emanuele Giurisato, William Vermi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
metastatic melanoma
BRAF
mutation
NGS
BRAF inhibitors
MEK inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01056/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01056/full

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