In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

Abstract We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 nonsyndromic hearing loss and deafness. Th...

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Bibliographic Details
Main Authors: Giulia Crispino, Fabian Galindo Ramirez, Matteo Campioni, Veronica Zorzi, Mark Praetorius, Giovanni Di Pasquale, John A. Chiorini, Fabio Mammano
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06759-y

Internet

https://doi.org/10.1038/s41598-017-06759-y

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