Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach

Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach

Purpose: Sorafenib is the sole FDA approved drug conventionally used for the treatment of advanced hepatocellular carcinoma (HCC). Despite of the beneficial use of sorafenib in the treatment of HCC, multidrug resistance still remains a challenge. HCC is inherently known as chemotherapy resistant tum...

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Bibliographic Details
Main Authors: Bhagyalakshmi Nair, Ruby John Anto, Sabitha M, Lekshmi R. Nath
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-05-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
hepatocellular carcinoma
sorafenib
kaempferol
multi-drug resistance
combination therapy
p-gp inhibitors
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-28286

Internet

https://apb.tbzmed.ac.ir/PDF/apb-28286

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