Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear. We utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence of resistance and transmission networks of MD...

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Bibliographic Details
Main Authors: Matthias Merker, Maxime Barbier, Helen Cox, Jean-Philippe Rasigade, Silke Feuerriegel, Thomas Andreas Kohl, Roland Diel, Sonia Borrell, Sebastien Gagneux, Vladyslav Nikolayevskyy, Sönke Andres, Ulrich Nübel, Philip Supply, Thierry Wirth, Stefan Niemann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
M. tuberculosis
drug resistance
MDR-TB
compensatory evolution
Online Access:https://elifesciences.org/articles/38200

Internet

https://elifesciences.org/articles/38200

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