Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

BackgroundGraft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogenei...

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Bibliographic Details
Main Authors: Aude Burlion, Simon Brunel, Nicolas Y. Petit, Daniel Olive, Gilles Marodon
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
graft-vs-host disease
graft vs leukemia effect
antibodies
monoclonal
mice
NSG
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00756/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00756/full

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