Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Several new immunodeficient mouse models for human cell engraftment have recently been introduced that include the Rag2(-/-)γc(-/-), NOD/SCID, NOD/SCIDγc(-/-) and NOD/SCIDβ2m(-/-) strains. Transplantation of these mice with CD34(+) human hematopoietic stem cells leads to prolonged engraftment, multi...

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Bibliographic Details
Main Authors: Ramesh Akkina, Bradford K Berges, Brent E Palmer, Leila Remling, C Preston Neff, Jes Kuruvilla, Elizabeth Connick, Joy Folkvord, Kathy Gagliardi, Afework Kassu, Sarah R Akkina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3114781?pdf=render

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http://europepmc.org/articles/PMC3114781?pdf=render

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