The CCL2 synthesis inhibitor <it>bindarit</it> targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis

The CCL2 synthesis inhibitor <it>bindarit</it> targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Production of the chemokine CCL2 by cells of the neurovascular unit (NVU) drives critical aspects of neuroinflammation. Suppression of CCL2 therefore holds promise in treating neuroinflammatory disease. Accordingly, we sought to dete...

Full description

Bibliographic Details
Main Authors: Ge Shujun, Shrestha Bandana, Paul Debayon, Keating Carolyn, Cone Robert, Guglielmotti Angelo, Pachter Joel S
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Neuroinflammation
Subjects:
CCL2
Neuroinflammation
Blood–brain barrier
Neurovascular unit
Brain microvascular endothelial cells
Astrocytes
Microglia
Online Access:http://www.jneuroinflammation.com/content/9/1/171

Internet

http://www.jneuroinflammation.com/content/9/1/171

Similar Items