SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

Abstract Background Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these effects, a microarray-based transcriptomics approach was used to identify...

Full description

Bibliographic Details
Main Authors: Domenico Sergi, Fiona M. Campbell, Christine Grant, Amanda C. Morris, Eva-Maria Bachmair, Christiane Koch, Fiona H. McLean, Aifric Muller, Nigel Hoggard, Baukje de Roos, Begona Porteiro, Mark V. Boekschoten, Fiona C. McGillicuddy, Darcy Kahn, Phyllis Nicol, Jonas Benzler, Claus-Dieter Mayer, Janice E. Drew, Helen M. Roche, Michael Muller, Ruben Nogueiras, Carlos Dieguez, Alexander Tups, Lynda M. Williams
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genes & Nutrition
Subjects:
SerpinA3N
Hypothalamus
High-fat diet
Leptin
Online Access:http://link.springer.com/article/10.1186/s12263-018-0619-1

Internet

http://link.springer.com/article/10.1186/s12263-018-0619-1

Similar Items