Liver-Targeting Class I Selective Histone Deacetylase Inhibitors Potently Suppress Hepatocellular Tumor Growth as Standalone Agents

Liver-Targeting Class I Selective Histone Deacetylase Inhibitors Potently Suppress Hepatocellular Tumor Growth as Standalone Agents

Dysfunctions in epigenetic regulation play critical roles in tumor development and progression. Histone deacetylases (HDACs) and histone acetyl transferase (HAT) are functionally opposing epigenetic regulators, which control the expression status of tumor suppressor genes. Upregulation of HDAC activ...

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Bibliographic Details
Main Authors: Subhasish Tapadar, Shaghayegh Fathi, Bocheng Wu, Carrie Q. Sun, Idris Raji, Samuel G. Moore, Rebecca S. Arnold, David A. Gaul, John A. Petros, Adegboyega K. Oyelere
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
hepatocellular cancer
histone deacetylase
histone deacetylase isoforms
histone deacetylase inhibitors
zinc binding group
molecular docking
Online Access:https://www.mdpi.com/2072-6694/12/11/3095

Internet

https://www.mdpi.com/2072-6694/12/11/3095

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