R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency

R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency

Abstract Background R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile ar...

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Bibliographic Details
Main Authors: Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young, Nadine Binart
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Ovarian Research
Subjects:
Primary ovarian insufficiency (POI)
RSPO2
Folliculogenesis
Genetic variants
Online Access:http://link.springer.com/article/10.1186/s13048-017-0345-0

Internet

http://link.springer.com/article/10.1186/s13048-017-0345-0

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