Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper considers the hypothesis that viral binding to cell-surface integrins may contribute to the high infectivity and widesp...

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Bibliographic Details
Main Authors: Lee Makowski, William Olson-Sidford, John W.-Weisel
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
COVID-19
spike protein
receptor-binding domain
RGD motif
integrins
coagulation
Online Access:https://www.mdpi.com/1999-4915/13/2/146

Internet

https://www.mdpi.com/1999-4915/13/2/146

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