Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma

Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma

Abstract Background Ras activation is a frequent event in hepatocellular carcinoma (HCC). Combining a RAS inhibitor with traditional clinical therapeutics might be hampered by a variety of side effects, thus hindering further clinical translation. Herein, we report on integrating an IR820 nanocapsul...

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Bibliographic Details
Main Authors: Bolin Wu, Yanchi Yuan, Jiayin Liu, Haitao Shang, Jing Dong, Xitian Liang, Dongxu Wang, Yichi Chen, Chunyue Wang, Yang Zhou, Hui Jing, Wen Cheng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Hepatocellular carcinoma
Sonodynamic therapy
scRNA-seq
RAS inhibitor
Online Access:https://doi.org/10.1186/s12951-021-00923-3

Internet

https://doi.org/10.1186/s12951-021-00923-3

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