Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling

Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling

Cardiac allograft vasculopathy (CAV) charactered with aberrant remodeling and fibrosis usually leads to the loss of graft after heart transplantation. Our previous work has reported that extracellular high-mobility group box 1 (HMGB1) participated in the CAV progression via promoting inflammatory ce...

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Bibliographic Details
Main Authors: Huijuan Zou, Bingxia Ming, Jun Li, Yifan Xiao, Lin Lai, Ming Gao, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
HMGB1
TGF-β1
cardiac allograft vasculopathy
transplantation
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641973/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.641973/full

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