Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Summary: Bile acids (BAs) are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. Differently structured BA species display variable signaling activities via farnesoid X receptor (FXR) and Takeda G protein-coupled BA receptor 1 (TGR5). This study profi...

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Bibliographic Details
Main Authors: Lianmin Chen, Inge C.L. van den Munckhof, Kiki Schraa, Rob ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V. Zhernakova, Alexander Kurilshikov, Vincent W. Bloks, Albert K. Groen, Niels P. Riksen, Joost H.W. Rutten, Leo A.B. Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Jingyuan Fu, Folkert Kuipers
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
bile acids
genetics
gut microbiome
liver
enterohepatic circulation
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312018

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312018

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