R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

During kidney development, WNT/β-catenin signalling has to be tightly controlled to ensure proliferation and differentiation of nephron progenitor cells. Here, we show in mice that the signalling molecules RSPO1 and RSPO3 act in a functionally redundant manner to permit WNT/β-catenin signalling and...

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Bibliographic Details
Main Authors: Valerie PI Vidal, Fariba Jian-Motamedi, Samah Rekima, Elodie P Gregoire, Emmanuelle Szenker-Ravi, Marc Leushacke, Bruno Reversade, Marie-Christine Chaboissier, Andreas Schedl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
kidney development
wnt signaling
mesenchyme to epithelial transition
Online Access:https://elifesciences.org/articles/53895

Internet

https://elifesciences.org/articles/53895

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