The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.

Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new ligand classes remain to be discovered. Furthermore, nuclear receptors a...

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Bibliographic Details
Main Authors: Kurt Warnhoff, Hyun C Roh, Zuzana Kocsisova, Chieh-Hsiang Tan, Andrew Morrison, Damari Croswell, Daniel L Schneider, Kerry Kornfeld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5240932?pdf=render