Gene Set Enrichment Analysis of Interaction Networks Weighted by Node Centrality

Gene Set Enrichment Analysis of Interaction Networks Weighted by Node Centrality

Gene set enrichment analysis (GSEA) is a powerful tool to associate a disease phenotype to a group of genes/proteins. GSEA attributes a specific weight to each gene/protein in the input list that depends on a metric of choice, which is usually represented by quantitative expression data. However, ex...

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Bibliographic Details
Main Authors: Alessandra Zito, Marta Lualdi, Paola Granata, Dario Cocciadiferro, Antonio Novelli, Tiziana Alberio, Rosario Casalone, Mauro Fasano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Genetics
Subjects:
systems medicine
network medicine
gene set enrichment analysis
topological analysis
neurodevelopment
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.577623/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.577623/full

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