Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells

Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells

Cancer is a complex devastating disease with enormous treatment challenges, including chemo- and radiotherapeutic resistance. Combination therapy demonstrated a promising strategy to target hard-to-treat cancers and sensitize cancer cells to conventional anti-cancer drugs such as doxorubicin. This s...

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Bibliographic Details
Main Authors: Afnan H. El-Gowily, Samah A. Loutfy, Ehab M. M. Ali, Tarek M. Mohamed, Mohammed A. Mansour
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
autophagy
apoptosis
PI3K
tioconazole
chloroquine
doxorubicin
Online Access:https://www.mdpi.com/1424-8247/14/3/254

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https://www.mdpi.com/1424-8247/14/3/254

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