Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy

Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that links the cytoskeleton and the extracellular matrix in skeletal and cardiac muscles. The primary...

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Bibliographic Details
Main Authors: Fatima Amor, Ai Vu Hong, Guillaume Corre, Mathilde Sanson, Laurence Suel, Stephanie Blaie, Laurent Servais, Thomas Voit, Isabelle Richard, David Israeli
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Duchenne muscular dystrophy
Host gene
Biological interpretation of miRNA dysregulation
SREBP‐1
SREBP‐2
Lipid metabolism
Online Access:https://doi.org/10.1002/jcsm.12708

Internet

https://doi.org/10.1002/jcsm.12708

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