Doxycycline alters metabolism and proliferation of human cell lines.

The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells-including inhibition of the mitochondrial ribosome-there have been few reports on potential off-target effects at conc...

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Bibliographic Details
Main Authors: Ethan Ahler, William J Sullivan, Ashley Cass, Daniel Braas, Autumn G York, Steven J Bensinger, Thomas G Graeber, Heather R Christofk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669316?pdf=render