Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
How STING agonists exert anti-tumour effects remains unclear. Here, the authors show that STING agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial cells through the TNFalpha-TNFR1 signaling, while in primary tumors, additional inhibition of AKT i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24603-w |