Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells

Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells

Increasing evidence shows that targeting epigenetic changes including acetylation and deacetylation of core nucleosomal histones as well as Aurora kinases hold promise for improving the treatment of human cancers including ovarian cancer. We investigated whether the histone deacetylase (HDAC) inhibi...

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Bibliographic Details
Main Authors: Yanfang Li, Tao Liu, Cristina Ivan, Jie Huang, De-Yu Shen, John J. Kavanagh, Robert C. Bast, Siqing Fu, Wei Hu, Anil K. Sood
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Oncology
Subjects:
valproic acid
Aurora kinase inhibitor
ovarian cancer
cervical cancer
endometrial cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2013.00058/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2013.00058/full

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