Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As a result of the low cell permeability and poor bioavailability, the traditional inhibitors targeting the protein tyrosine ph...

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Bibliographic Details
Main Authors: Zhendong Song, Meijing Wang, Yang Ge, Xue-Ping Chen, Ziyang Xu, Yang Sun, Xiao-Feng Xiong
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SHP2
Phosphatase
Selectivity
Allosteric inhibitor
Tumor therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306523

Internet

http://www.sciencedirect.com/science/article/pii/S2211383520306523

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