KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma.

KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma.

Kaposi's sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi's sarcoma. Cyclooxygenase-2 (COX-2) is an inflammatory mediator that plays a ke...

Full description

Bibliographic Details
Main Authors: María Victoria Medina, Agata D Agostino, Qi Ma, Pilar Eroles, Lucas Cavallin, Chiara Chiozzini, Daiana Sapochnik, Cora Cymeryng, Elizabeth Hyjek, Ethel Cesarman, Julian Naipauer, Enrique A Mesri, Omar A Coso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009006

Internet

https://doi.org/10.1371/journal.ppat.1009006

Similar Items