A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

In epithelial cells Zeb1 is involved in the epithelial to mesenchymal transition. In this study, the authors show in a mouse model of breast cancer, that Zeb1 expression in stromal cells is required for tumour formation and metastasis.

Bibliographic Details
Main Authors: Rong Fu, Chen-Feng Han, Ting Ni, Lei Di, Li-Juan Liu, Wen-Cong Lv, Yan-Ran Bi, Nan Jiang, Yin He, Hong-Mei Li, Shui Wang, Hui Xie, Bao-An Chen, Xiao-Sheng Wang, Stephen J. Weiss, Tao Lu, Qing-Long Guo, Zhao-Qiu Wu
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11278-7

Internet

https://doi.org/10.1038/s41467-019-11278-7

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