Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons

Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons

Abstract Background Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruit...

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Bibliographic Details
Main Authors: Qiong Xu, Yuan-yuan Liu, Xiaoming Wang, Guo-he Tan, Hui-ping Li, Samuel W. Hulbert, Chun-yang Li, Chun-chun Hu, Zhi-qi Xiong, Xiu Xu, Yong-hui Jiang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Molecular Autism
Subjects:
CHD8
Autism spectrum disorder (ASD)
Chromatin remodeling
Neurite growth
Neurodevelopment
Online Access:http://link.springer.com/article/10.1186/s13229-018-0244-2

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http://link.springer.com/article/10.1186/s13229-018-0244-2

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