Mineralocorticoid Receptor Blockade Improves Insulin Sensitivity in the Rat Heart and a Possible Molecular Mechanism

Mineralocorticoid Receptor Blockade Improves Insulin Sensitivity in the Rat Heart and a Possible Molecular Mechanism

Background/Aims: Extensive research has explored the role of aldosterone in insulin resistance. Recent evidence suggests that the mineralocorticoid receptor (MR) mediates aldosterone-induced dysregulation of cytokines, and most of this research has focused on adjustments in fat tissue and adipocytes...

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Bibliographic Details
Main Authors: Mei Wang, Yongjun Li, Kun Zhou, Guoru Zhang, Yaling Wang, Tao Liu, Yang Zhang, Anjun Guo, Yu An
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
P38 mitogen-activated protein kinase
Insulin resistance
Mineralocorticoid receptor
Cardiomyocytes
Peroxisome proliferator-activated receptor α
Online Access:http://prod.karger.com/Article/FullText/447796

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http://prod.karger.com/Article/FullText/447796

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