Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This st...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-020-01618-5 |