The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...

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Bibliographic Details
Main Authors: Eliska Ruzickova, Nikola Skoupa, Petr Dolezel, Dennis A. Smith, Petr Mlejnek
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
tyrosine kinase inhibitors
lysosomal sequestration
drug resistance
target sites
extralysosomal space
extracellular space
Online Access:https://www.mdpi.com/2218-273X/9/11/675

Internet

https://www.mdpi.com/2218-273X/9/11/675

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