The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance
The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...
Main Authors: | Eliska Ruzickova, Nikola Skoupa, Petr Dolezel, Dennis A. Smith, Petr Mlejnek |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/9/11/675 |
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