Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells.

Marek's disease is one of the most common viral diseases of poultry affecting chicken flocks worldwide. The disease is caused by an alphaherpesvirus, the Marek's disease virus (MDV), and is characterized by the rapid onset of multifocal aggressive T-cell lymphoma in the chicken host. Altho...

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Bibliographic Details
Main Authors: Laëtitia Trapp-Fragnet, Djihad Bencherit, Danièle Chabanne-Vautherot, Yves Le Vern, Sylvie Remy, Elisa Boutet-Robinet, Gladys Mirey, Jean-François Vautherot, Caroline Denesvre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4063868?pdf=render