Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

We have studied the functional repercussions of cerebrovascular abnormalities in transgenic mice overexpressing TGF-β1. These mice develop Alzheimer's disease-like vascular and meningeal alterations without parenchymal degeneration. Autoradiographic cerebral blood flow measurements in 9-month-o...

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Bibliographic Details
Main Authors: Roger F. Gaertner, Tony Wyss-Coray, Dominique Von Euw, Sylvain Lesné, Denis Vivien, Pierre Lacombe
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Cerebral blood flow
Cerebral glucose utilization
Cerebral amyloid angiopathy
Cytokine
TGF-β1 transgenic mice
Thioflavin-S
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002761

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http://www.sciencedirect.com/science/article/pii/S0969996104002761

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