Correlations of <it>EGFR </it>mutations and increases in <it>EGFR </it>and <it>HER2 </it>copy number to gefitinib response in a retrospective analysis of lung cancer patients

Correlations of <it>EGFR </it>mutations and increases in <it>EGFR </it>and <it>HER2 </it>copy number to gefitinib response in a retrospective analysis of lung cancer patients

<p>Abstract</p> <p>Background</p> <p>Gefitinib, a small molecule tyrosine kinase inhibitor of the Epidermal Growth Factor Receptor (<it>EGFR</it>), has shown limited efficacy in the treatment of lung cancer. Recognized clinical predictors of response to this...

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Main Authors: English John, Melosky Barbara, Murray Nevin, Ho Cheryl, O'Connor Robert, Salski Chris, Fee John, Sutcliffe Margaret, Barclay Lorena, Bebb Gwyn, Pugh Trevor J, Vielkind Jeurgen, Horsman Doug, Laskin Janessa J, Marra Marco A
Format: Article
Language:English
Published: BMC 2007-07-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/7/128

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http://www.biomedcentral.com/1471-2407/7/128

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