Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes

Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes

A central feature of the immune synapse (IS) is the tight compartmentalization of membrane receptors and signaling mediators that is functional for its ability to coordinate T cell activation. Second messengers centrally implicated in this process, such as Ca2+ and diacyl glycerol, also undergo comp...

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Bibliographic Details
Main Authors: Vijay B. Arumugham, Cristina Ulivieri, Anna Onnis, Francesca Finetti, Fiorella Tonello, Daniel Ladant, Cosima T. Baldari
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
immune synapse
cyclic AMP
compartmentalization
T-cell antigen receptor signaling
adenylate cyclase toxin
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00919/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00919/full

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