Mechanisms of protein-folding diseases at a glance

For a protein to function appropriately, it must first achieve its proper conformation and location within the crowded environment inside the cell. Multiple chaperone systems are required to fold proteins correctly. In addition, degradation pathways participate by destroying improperly folded protei...

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Bibliographic Details
Main Authors: Julie S. Valastyan, Susan Lindquist
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/7/1/9