Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices. We performed next-generation panel sequencing of primary tumor tissue, pl...

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Bibliographic Details
Main Authors: Yongsheng Wang, Feng Jiang, Ruixue Xia, Ming Li, Chengyun Yao, Yan Li, Hui Li, Qi Zhao, Mingke Shi, Yanzhe Yu, Yang W. Shao, Guoren Zhou, Hongping Xia, Liyun Miao, Hourong Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
leptomeningeal metastasis
cerebrospinal fluid
liquid biopsy
cell-free DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.701171/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.701171/full

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