Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections.

Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections.

Infection with (SAg)-producing bacteria may precede or follow infection with or vaccination against influenza A viruses (IAVs). However, how SAgs alter the breadth of IAV-specific CD8+ T cell (TCD8) responses is unknown. Moreover, whether recall responses mediating heterosubtypic immunity to IAVs ar...

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Bibliographic Details
Main Authors: Courtney E Meilleur, Arash Memarnejadian, Adil N Shivji, Jenna M Benoit, Stephen W Tuffs, Tina S Mele, Bhagirath Singh, Jimmy D Dikeakos, David J Topham, Hong-Hua Mu, Jack R Bennink, John K McCormick, S M Mansour Haeryfar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008393

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https://doi.org/10.1371/journal.ppat.1008393

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