Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

Summary: Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling evidence has implicated extracellular vesicles (EVs...

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Bibliographic Details
Main Authors: Naureen Javeed, Tracy K. Her, Matthew R. Brown, Patrick Vanderboom, Kuntol Rakshit, Aoife M. Egan, Adrian Vella, Ian Lanza, Aleksey V. Matveyenko
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
extracellular vesicles
β cell
inflammation
diabetes
intercellular communication
CXCL10
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010512

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http://www.sciencedirect.com/science/article/pii/S2211124721010512

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