The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferi

The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferi

BosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. Unlike typical Fur proteins in which DNA binding represses gene expression, binding of BosR to the rpoS promoter directly activates rpoS transcription in B. burgdorferi. However, virtuall...

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Bibliographic Details
Main Authors: Charlotte Mason, Xiaoyan Liu, Spoorthy Prabhudeva, Zhiming Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Lyme disease
spirochetes
Borrelia burgdorferi
gene expression
gene regulation
pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00109/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00109/full

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