HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca2+-ATPase Activity in Cardiac Myocytes

HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca2+-ATPase Activity in Cardiac Myocytes

SERCA2a is the Ca2+ ATPase playing the major contribution in cardiomyocyte (CM) calcium removal. Its activity can be regulated by both modulatory proteins and several post-translational modifications. The aim of the present work was to investigate whether the function of SERCA2 can be modulated by t...

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Bibliographic Details
Main Authors: Viviana Meraviglia, Leonardo Bocchi, Roberta Sacchetto, Maria Cristina Florio, Benedetta M. Motta, Corrado Corti, Christian X. Weichenberger, Monia Savi, Yuri D’Elia, Marcelo D. Rosato-Siri, Silvia Suffredini, Chiara Piubelli, Giulio Pompilio, Peter P. Pramstaller, Francisco S. Domingues, Donatella Stilli, Alessandra Rossini
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
SERCA2
acetylation
HDAC inhibition
ATPase activity
calcium transients
cardiomyocyte mechanics
Online Access:http://www.mdpi.com/1422-0067/19/2/419

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http://www.mdpi.com/1422-0067/19/2/419

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