Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role in both bone homeostasis and inflammatory dis...

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Bibliographic Details
Main Authors: Heeseog Kang, Audrey Kerloc’h, Maxime Rotival, Xiaoqing Xu, Qing Zhang, Zelpha D’Souza, Michael Kim, Jodi Carlson Scholz, Jeong-Hun Ko, Prashant K. Srivastava, Jonathan R. Genzen, Weiguo Cui, Timothy J. Aitman, Laurence Game, James E. Melvin, Adedayo Hanidu, Janice Dimock, Jie Zheng, Donald Souza, Aruna K. Behera, Gerald Nabozny, H. Terence Cook, J.H. Duncan Bassett, Graham R. Williams, Jun Li, Agnès Vignery, Enrico Petretto, Jacques Behmoaras
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714006160

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