Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness

Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness

Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of individuals in the extremes of cIMT trait distributio...

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Bibliographic Details
Main Authors: Dina Vojinovic, Maryam Kavousi, Mohsen Ghanbari, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Wilfred F. J. van Ijcken, Andre G. Uitterlinden, Cornelia M. van Duijn, Najaf Amin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
atherosclerosis
intima-media thickness
genetics
linkage
exome sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00420/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00420/full

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