Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat/rev Genes for an HIV-1 Gene Therapy Approach

Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat/rev Genes for an HIV-1 Gene Therapy Approach

Gene therapy holds considerable promise for the functional cure of HIV-1 infection and, in this context, RNA interference (RNAi)-based approaches represent powerful strategies. Stable expression of small interfering RNAs (siRNAs) targeting HIV genes or cellular cofactors has the potential to render...

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Bibliographic Details
Main Authors: Francesca Spanevello, Arianna Calistri, Claudia Del Vecchio, Barbara Mantelli, Chiara Frasson, Giuseppe Basso, Giorgio Palù, Marina Cavazzana, Cristina Parolin
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300380

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http://www.sciencedirect.com/science/article/pii/S2162253117300380

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