Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo

Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo

We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also ind...

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Bibliographic Details
Main Authors: O-Yu Kwon, Kweon Yu, Seung-Whan Kim, Tae-Won Goo, Young Jin Choi, Kyeong Ryong Lee, Kisang Kwon, Dae Young Hong
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:International Journal of Molecular Sciences
Subjects:
lidocaine
endoplasmic reticulum (ER) stress
ER chaperone
ER stress sensor
apoptosis
Online Access:http://www.mdpi.com/1422-0067/12/11/7652/

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http://www.mdpi.com/1422-0067/12/11/7652/

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