Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide

Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide

The synthetic peptide T11F (TCRVDHRGLTF), derived from the constant region of human IgM antibodies, proved to exert a significant activity in vitro against yeast strains, including multidrug resistant isolates. Alanine substitution of positively charged residues led to a decrease in candidacidal act...

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Bibliographic Details
Main Authors: Thelma A. Pertinhez, Tecla Ciociola, Laura Giovati, Walter Magliani, Silvana Belletti, Luciano Polonelli, Stefania Conti, Alberto Spisni
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
antibody-derived peptides
antifungal peptides
cell penetrating peptides
circular dichroism
nuclear magnetic resonance spectroscopy
confocal microscopy
scanning electron microscopy
Online Access:https://www.mdpi.com/1422-0067/19/12/3792

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https://www.mdpi.com/1422-0067/19/12/3792

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