Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo tumor models

Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo tumor models

Abstract Objective A dual inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor 1 receptor (IGF-1R), TAE226, was evaluated in a panel of cancer cell lines, MIA PaCa-2 human pancreatic tumor and 4T1 murine breast tumor models. The profiling data were generated during the drug discov...

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Bibliographic Details
Main Authors: Shigemi Fukami, Daisaku Tomioka, Yutaka Murakami, Toshiyuki Honda, Shinji Hatakeyama
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Research Notes
Subjects:
Focal adhesion kinase
Insulin-like growth factor-1 receptor
Cell proliferation
Anti-tumor
Online Access:http://link.springer.com/article/10.1186/s13104-019-4389-7

Internet

http://link.springer.com/article/10.1186/s13104-019-4389-7

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