MOLECULAR MECHANISMS OF INHIBITION OF COLLAGEN CLEAVAGE ACTIVITY BY DEFEROXAMINE IN THE CARTILAGE OF PATIENTS WITH OSTEOARTHRITIS

MOLECULAR MECHANISMS OF INHIBITION OF COLLAGEN CLEAVAGE ACTIVITY BY DEFEROXAMINE IN THE CARTILAGE OF PATIENTS WITH OSTEOARTHRITIS

Objective: to study the molecular mechanisms underlying the suppression of collagenase activity in the presence of deferoxamine (DFO) in articular cartilage explants from patients with osteoarthritis (OA).Subjects and methods. The knee joint cartilage obtained during arthroplasty from 33 patients (m...

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Bibliographic Details
Main Authors: E. V. Chetina, G. A. Markova, A. L. Logunov, V. V. Kolomatsky, E. A. Naryshkin, S. A. Makarov, A. N. Kuzin
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2017-03-01
Series:Научно-практическая ревматология
Subjects:
osteoarthritis
gene expression
articular cartilage explants
proteases
x type collagen
proinflammatory cytokines
glycolysis
tricarboxylic acid cycle
Online Access:https://rsp.mediar-press.net/rsp/article/view/2338

Internet

https://rsp.mediar-press.net/rsp/article/view/2338

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